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abca1  (Cell Signaling Technology Inc)


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    Structured Review

    Cell Signaling Technology Inc abca1
    Abca1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 57 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+abca1+antibody/ABCA1+Rabbit+mAb/pm41832981-71-10-12
    Average 95 stars, based on 57 article reviews
    abca1 - by Bioz Stars, 2026-09
    95/100 stars

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    Related Articles

    Western Blot:

    Article Title: Suppression of hepatic PPARα by hypoxia disrupts cholesterol metabolism and indirectly impairs arterial endothelial function in MASLD.
    Article Snippet: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD).. Currently, no approved targeted therapeutic interventions exist for MASLD.. Hypoxia is known to exacerbate the progression of both MASLD and ASCVD.

    cDNA Synthesis:

    Article Title: AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring AUF-1-Dicer-1-miR122 hierarchy
    Article Snippet: QIAamp stool mini kit was purchased from Qiagen (Hilden, Germany). .. Prime script first strand cDNA synthesis kit, TB Green Premix ex-Taq (Tli RNase H+) qPCR kit were purchased from Takara (Shiga, Japan). (Ripa lysis buffer, anti-β-actin antibody (polyclonal), siAUF1, Anti-AUF1 antibody (rabbit polyclonal), anti-HMGCR antibody (polyclonal), anti-ABCA1 antibody (rabbit monoclonal) were purchased from Cell Signalling Technology (Danvers, MA, USA). .. Anti-ABCA-5 antibody (rabbit, polyclonal) was purchased from Abcam (Cambridge, UK).

    Real-time Polymerase Chain Reaction:

    Article Title: AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring AUF-1-Dicer-1-miR122 hierarchy
    Article Snippet: QIAamp stool mini kit was purchased from Qiagen (Hilden, Germany). .. Prime script first strand cDNA synthesis kit, TB Green Premix ex-Taq (Tli RNase H+) qPCR kit were purchased from Takara (Shiga, Japan). (Ripa lysis buffer, anti-β-actin antibody (polyclonal), siAUF1, Anti-AUF1 antibody (rabbit polyclonal), anti-HMGCR antibody (polyclonal), anti-ABCA1 antibody (rabbit monoclonal) were purchased from Cell Signalling Technology (Danvers, MA, USA). .. Anti-ABCA-5 antibody (rabbit, polyclonal) was purchased from Abcam (Cambridge, UK).

    Lysis:

    Article Title: AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring AUF-1-Dicer-1-miR122 hierarchy
    Article Snippet: QIAamp stool mini kit was purchased from Qiagen (Hilden, Germany). .. Prime script first strand cDNA synthesis kit, TB Green Premix ex-Taq (Tli RNase H+) qPCR kit were purchased from Takara (Shiga, Japan). (Ripa lysis buffer, anti-β-actin antibody (polyclonal), siAUF1, Anti-AUF1 antibody (rabbit polyclonal), anti-HMGCR antibody (polyclonal), anti-ABCA1 antibody (rabbit monoclonal) were purchased from Cell Signalling Technology (Danvers, MA, USA). .. Anti-ABCA-5 antibody (rabbit, polyclonal) was purchased from Abcam (Cambridge, UK).



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    Schematic of the anti-atherosclerotic mechanism of OPN-HMCN@MLT. ( A ) The study commenced with the synthesis of mesoporous carbon nanospheres (MCN) functionalized with an OPN-binding peptide and hyaluronic acid to construct the OPN-HMCN nanoplatform. The OPN-binding peptide was designed to recognize OPN enriched in the extracellular matrix and on the surface of foam cells, thereby enabling selective accumulation in OPN-rich pathological regions. Following OPN recognition, OPN-HMCN@MLT undergoes CD44-dependent endocytosis. Melatonin (MLT), a lipid autophagy–promoting agent, was subsequently encapsulated within the nanocarrier to form OPN-HMCN@MLT. Firstly, the released MLT can bind to and upregulate the expression of PPARα and PPARγ, which then promote the expression of downstream genes <t>(ABCA1,</t> ABCG1, ACOX-1, and CTP1A) and trigger the lipophagy. ( B ) Subsequently, its lipophagy-enhancing effects, including ABCA1/G1-mediated cholesterol efflux and CTP1A/ACOX-1-mediated mitochondrial fatty acid oxidation, were studied to confirm the reversal of foam cell formation. ( C ) These effects eventually promote foam cells to reverse into macrophages. Abbreviations: MCN, mesoporous carbon nanoparticle; OPN, osteopontin; MLT, melatonin; LDL, low-density lipoprotein; ox-LDL, oxidized low-density lipoprotein; PA, Photoacoustic.
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    Image Search Results


    Schematic of the anti-atherosclerotic mechanism of OPN-HMCN@MLT. ( A ) The study commenced with the synthesis of mesoporous carbon nanospheres (MCN) functionalized with an OPN-binding peptide and hyaluronic acid to construct the OPN-HMCN nanoplatform. The OPN-binding peptide was designed to recognize OPN enriched in the extracellular matrix and on the surface of foam cells, thereby enabling selective accumulation in OPN-rich pathological regions. Following OPN recognition, OPN-HMCN@MLT undergoes CD44-dependent endocytosis. Melatonin (MLT), a lipid autophagy–promoting agent, was subsequently encapsulated within the nanocarrier to form OPN-HMCN@MLT. Firstly, the released MLT can bind to and upregulate the expression of PPARα and PPARγ, which then promote the expression of downstream genes (ABCA1, ABCG1, ACOX-1, and CTP1A) and trigger the lipophagy. ( B ) Subsequently, its lipophagy-enhancing effects, including ABCA1/G1-mediated cholesterol efflux and CTP1A/ACOX-1-mediated mitochondrial fatty acid oxidation, were studied to confirm the reversal of foam cell formation. ( C ) These effects eventually promote foam cells to reverse into macrophages. Abbreviations: MCN, mesoporous carbon nanoparticle; OPN, osteopontin; MLT, melatonin; LDL, low-density lipoprotein; ox-LDL, oxidized low-density lipoprotein; PA, Photoacoustic.

    Journal: Bioactive Materials

    Article Title: A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques

    doi: 10.1016/j.bioactmat.2026.02.041

    Figure Lengend Snippet: Schematic of the anti-atherosclerotic mechanism of OPN-HMCN@MLT. ( A ) The study commenced with the synthesis of mesoporous carbon nanospheres (MCN) functionalized with an OPN-binding peptide and hyaluronic acid to construct the OPN-HMCN nanoplatform. The OPN-binding peptide was designed to recognize OPN enriched in the extracellular matrix and on the surface of foam cells, thereby enabling selective accumulation in OPN-rich pathological regions. Following OPN recognition, OPN-HMCN@MLT undergoes CD44-dependent endocytosis. Melatonin (MLT), a lipid autophagy–promoting agent, was subsequently encapsulated within the nanocarrier to form OPN-HMCN@MLT. Firstly, the released MLT can bind to and upregulate the expression of PPARα and PPARγ, which then promote the expression of downstream genes (ABCA1, ABCG1, ACOX-1, and CTP1A) and trigger the lipophagy. ( B ) Subsequently, its lipophagy-enhancing effects, including ABCA1/G1-mediated cholesterol efflux and CTP1A/ACOX-1-mediated mitochondrial fatty acid oxidation, were studied to confirm the reversal of foam cell formation. ( C ) These effects eventually promote foam cells to reverse into macrophages. Abbreviations: MCN, mesoporous carbon nanoparticle; OPN, osteopontin; MLT, melatonin; LDL, low-density lipoprotein; ox-LDL, oxidized low-density lipoprotein; PA, Photoacoustic.

    Article Snippet: To block nonspecific binding, membranes were incubated with 5% skim milk for 1 h. Thereafter, membranes were incubated overnight at 4 °C with primary antibodies against ABCA1, ABCG1, ACOX1, CPT1A, LC3 (ab192890, 1:2000, abcam), LAMP1 (84658-5-RR, 1:8000, Proteintech), PPARα (66826-1-Ig, 1:3000, Proteintech), PPARγ (66936-1-Ig, 1:10000, Proteintech), P62 (18420-1-AP, 1:10000, Proteintech), MCAD (55210-1-AP, 1:3000, Proteintech), LCAD (17526-1-AP, 1:10000, Proteintech), tubulin (80762-1-RR, 1:10000, Proteintech), GAPDH (60004-1-Ig, 1:50000, Proteintech), and β-actin (66009-1-Ig, 1:20000, Proteintech).

    Techniques: Binding Assay, Construct, Expressing